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ForumsDosing & ProtocolsAir bubbles in syringe — 12 month update Page 3

Air bubbles in syringe — 12 month update

fiona_glasgow Wed, Sep 11, 2024 at 12:21 PM 48 replies 2,979 viewsPage 3 of 10
NeuroNate
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Sep 13, 2024 at 12:37 AM#11
claudia_zurich said:
Ongoing cost tracking for dosing arithmetic — transparency for the community: Monthly medication cost: $110 Supplies (syringes, BAC water, alcohol…

Regarding dosing arithmetic multi-dose vial contamination prevention: after reconstituting, I wipe the vial stopper with a fresh alcohol swab before EVERY single draw. I also never touch the stopper with my fingers and use a new needle for each draw.

Even with bacteriostatic water preservative, contamination is cumulative. One sloppy draw can introduce bacteria that multiply over days. Aseptic technique isn't optional — it's essential for injectable medications.

Last edited: Sep 13, 2024 at 6:37 AM
25 23jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 22 others
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GenomicsKate
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Sep 14, 2024 at 7:52 AM#12
B12Beth said:
The arithmetic is right and one caveat matters: a U-40 syringe changes the markings, not the volumes.

Saving this. It is the first explanation that did not require me to already understand it. I will report back once I have actually tried it.

Last edited: Sep 14, 2024 at 12:52 PM
26 24KristenIndy, MarkLI_maint, Dr.PeteFamMed and 23 others
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roxy_nash
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Sep 15, 2024 at 3:08 PM#13
claudia_zurich said:
Ongoing cost tracking for dosing arithmetic — transparency for the community: Monthly medication cost: $110 Supplies (syringes, BAC water, alcohol…

Reconstitution tip for anyone mixing dosing arithmetic from lyophilized powder: use bacteriostatic water, NOT sterile water. The benzyl alcohol in BAC water preserves multi-dose vials for up to 28 days.

Inject the water slowly down the side of the vial. NEVER shake — gentle swirling only until fully dissolved. Should be crystal clear with no particles.

27 0tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 24 others
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Sigma-Aldrich — Research-Grade Standards

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raj_cambridge
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Sep 16, 2024 at 10:24 PM#14
fiona_glasgow said:
I reconstituted a 10mg vial with 2ml of bacteriostatic water and I want someone to check my unit arithmetic before I draw anything, because I keep…

Bacteriostatic water quality matters for dosing arithmetic reconstitution. Not all BAC water is created equal:

  • Should contain 0.9% benzyl alcohol as preservative
  • Must be sterile and pyrogen-free
  • Should come in a sealed, intact vial
  • Check expiration date — yes, BAC water expires
  • Store at room temperature, protected from light

I buy from a reputable medical supply company, not Amazon marketplace sellers. The $3 savings isn't worth the infection risk from unverified BAC water.

Last edited: Sep 16, 2024 at 11:24 PM
28 1PharmHunterJen, TomTeleRx, DoseLogDan and 25 others
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Admin
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Sep 18, 2024 at 5:41 AM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Carry on.

29 2PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 26 others
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