I split my weekly dose in half for six weeks to see whether it smoothed the first two days out, and the result was less impressive than I expected.
The narrow version of the question is what the pharmacokinetic argument against splitting a weekly dose actually is, since intuitively it should smooth the curve.
I have searched first, so if this is covered somewhere point me at it and I will read it.
Answering the narrow version, because the broad one does not have a single answer. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.
SarahChen_PharmD said:Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
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Shop Reference StandardsDr.ObesityMed said:I split my weekly dose in half for six weeks to see whether it smoothed the first two days out, and the result was less impressive than I expected.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
From the other side of the consultation, briefly.
Dose splitting update on split dosing: instead of 2.4mg once weekly, I've been doing 1.2mg twice weekly (Mon/Thu) with my doctor's approval. The appetite suppression is more consistent and side effects are noticeably milder.
Not medical advice, just sharing what's worked for me. Discuss with your provider before trying this.