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ForumsDosing & ProtocolsAir bubbles in syringe — 12 month update Page 2

Air bubbles in syringe — 12 month update

fiona_glasgow Wed, Sep 11, 2024 at 12:21 PM 48 replies 2,979 viewsPage 2 of 10
DebRD_ATL
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Sep 11, 2024 at 1:37 PM#6
TrialTracker_MD said:
Dead space is the answer to the missing dose.

I am going to disagree with reconstituting low as a general rule. More diluent, more punctures, more in-use days at room temperature, and the stability trade-off is real. Precision is not the only variable being optimised.

Last edited: Sep 11, 2024 at 5:37 PM
33 3BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 30 others
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Dr.RaviCardio
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Sep 11, 2024 at 2:06 PM#7
fiona_glasgow said:
I reconstituted a 10mg vial with 2ml of bacteriostatic water and I want someone to check my unit arithmetic before I draw anything, because I keep…

For anyone reconstituting dosing arithmetic peptides: the water-to-powder ratio determines your concentration. Here's my reference:

Vial SizeBAC WaterConcentration0.25mg Dose
5mg2mL2.5mg/mL10 units
5mg2.5mL2mg/mL12.5 units
10mg2mL5mg/mL5 units
10mg3mL3.33mg/mL7.5 units

More water = easier to measure small doses but vial runs out faster. Find the balance that works for your dose.

Last edited: Sep 11, 2024 at 3:06 PM
32 2anna.melb_AU, mark_tokyo, hans_munich and 29 others
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claudia_zurich
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Sep 11, 2024 at 2:35 PM#8
DebRD_ATL said:
I am going to disagree with reconstituting low as a general rule.

Ongoing cost tracking for dosing arithmetic — transparency for the community:

Monthly medication cost: $110
Supplies (syringes, BAC water, alcohol swabs): ~$8/month
Janoshik testing: ~$10/month (amortized quarterly)
Lab work: ~$50/month (amortized quarterly)
Total: ~$210/month

Compare to brand Wegovy at $1250/month without insurance. Compounded is roughly 85% cheaper for what I have found to be clinically equivalent medication.

31 1Dr.LipidDallas, alex_tucson, kevin_tulsa and 28 others
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Sigma-Aldrich — Research-Grade Standards

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FranDenver
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Oct 2024
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Sep 11, 2024 at 3:04 PM#9

One thing that is still open after B12Beth’s answer:

How to check the arithmetic without trusting a website calculator, since three calculators gave me three answers?

Last edited: Sep 11, 2024 at 9:04 PM
30 0MASHdoc_SA, GenomicsKate, Dr.ObesityMed and 27 others
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fiona_glasgow
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Sep 11, 2024 at 5:23 PM#10

OP back with an update, since a thread like this is useless without one.

My error was treating units as a mass. Once I wrote mg/ml on the vial in marker and worked in millilitres first, the two of us got the same answer.

Last edited: Sep 11, 2024 at 10:23 PM
24 22NeuroNate, JessicaH_TX, KevinCompounds and 21 others
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