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ForumsDosing & ProtocolsTirzepatide titration: 2.5→5→7.5→10→12.5→15mg guide Page 5

Tirzepatide titration: 2.5→5→7.5→10→12.5→15mg guide

Dr.Martinez Mon, Feb 19, 2024 at 5:20 PM 181 replies 34,127 viewsPage 5 of 20
Dr.PeteFamMed
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Feb 28, 2024 at 8:04 AM#21

The figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

Last edited: Feb 28, 2024 at 9:04 AM
8 8hyun_seoul, jim_asheville, matt_MKE and 5 others
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raj_cambridge
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Jun 2024
Cambridge, MA
Mar 1, 2024 at 12:38 PM#22

A narrower follow-up, since the general answer is now clear:

How much of the tirzepatide advantage is the GIP component and how much is simply that the dose ladder goes higher in receptor-occupancy terms?

Last edited: Mar 1, 2024 at 1:38 PM
7 7DoseLogDan, SleepFixSam, PurityPaulOR and 4 others
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tane_welly
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Wellington, NZ
Mar 3, 2024 at 5:11 PM#23
Dr.PeteFamMed said:
Practical: whatever you change, write down the date and the reason.

This is where I part company with the consensus forming above. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

Correct me if the detail matters more than I have assumed.

6 6DanielChem_CHI, marco_milano, pam_columbus and 3 others
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josh_phd_bmore
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Baltimore, MD
Mar 5, 2024 at 9:43 PM#24
Dr.PeteFamMed said:
Practical: whatever you change, write down the date and the reason.

Agreeing with Dr.PeteFamMed, and the qualification matters more than the agreement. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

5 5KarenAZ_mom, zoe_NC, Dr.ObesityLA and 2 others
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VanRx_Mike
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Vancouver, CA
Mar 8, 2024 at 2:14 AM#25
Dr.PeteFamMed said:
Practical: whatever you change, write down the date and the reason.

Bookmarking. The distinction being drawn above is the one nobody else makes. Sending this to two other people who asked me the same thing last week.

4 4mike_mod, SarahChen_PharmD, sarah.morrison and 1 other
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