Has anyone dealt with moisture content analysis for lyophilized peptides?

sean_dublin said:

The mechanism and the magnitude are separate questions.

Same pattern here, and in the same order.

sean_dublin said:

The mechanism and the magnitude are separate questions.

There is a second half to this that has not been said yet. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Following on from sean_dublin — and this may be the naive question:

What would you measure differently if you were starting again?

Closing the loop on my own question.

Update — I was wrong in the opening post, specifically about the direction. Correcting it here rather than editing it away.