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ForumsCOA & Analytical TestingLC-MS/MS vs HPLC for peptide analysis — November 2025 Page 10

LC-MS/MS vs HPLC for peptide analysis — November 2025

Dr.SportsMedIN Mon, Jul 22, 2024 at 3:37 PM 51 replies 2,260 viewsPage 10 of 11
jim_asheville
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Jan 25, 2025 at 4:30 AM#46

Clinical perspective, offered as context rather than as advice. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

9 7MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 6 others
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Dr.SportsMedIN
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Jan 31, 2025 at 8:07 PM#47

OP back with an update, since a thread like this is useless without one.

Update — I was wrong in the opening post, specifically about the direction. Correcting it here rather than editing it away.

10 8lisa_labSD, adam_van, Dr.SurgeonPGH and 7 others
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Dr.Martinez
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Feb 7, 2025 at 11:41 AM#48
jim_asheville said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Coming at jim_asheville’s question from a different direction. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Ask again with the specifics and you will get a better answer than this one.

11 9rachel_ABQ, traveltech_sara, AttorneyGrant and 8 others
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bri_stats
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Feb 14, 2025 at 3:11 AM#49

The figures, for anyone assembling their own picture. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

12 10JessicaM_2024, TomFromTexas, mike.trainer_LA and 9 others
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chris_chi24
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Feb 20, 2025 at 6:37 PM#50

A narrower follow-up, since the general answer is now clear:

What would you measure differently if you were starting again?

Last edited: Feb 20, 2025 at 9:37 PM
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