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ForumsMASH / Liver DiseaseMASH resolution without worsening fibrosis — looking for input Page 5

MASH resolution without worsening fibrosis — looking for input

PeptideSynthNJ Wed, Jul 2, 2025 at 8:50 AM 40 replies 1,673 viewsPage 5 of 8
BenResearch_OR
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Jul 23, 2025 at 9:29 PM#21
wendy_avl said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Thank you for spelling out the reasoning rather than just the conclusion. Taking it to my next appointment.

18 16julia.endo, JessicaM_2024, TomFromTexas and 15 others
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NurseKim_ATL
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Jul 30, 2025 at 1:57 PM#22

From the other side of the consultation, briefly. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

19 17raj_cambridge, ingrid_STO, pete_nash and 16 others
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mona_PHX
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Aug 6, 2025 at 6:21 AM#23
NurseKim_ATL said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Same pattern here, and in the same order.

20 18SallyK_inj, CryptoCarl, MariaRD and 17 others
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SkepticalSean
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Aug 12, 2025 at 10:41 PM#24
NurseKim_ATL said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Adding the part of the answer the thread has not reached. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

21 19tammy_FL, Dr.LipidDallas, alex_tucson and 18 others
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lisa_labSD
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San Diego, CA
Aug 19, 2025 at 2:57 PM#25

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

22 20cory_ATX, lori_vegas, Dr.PulmRoch and 19 others
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