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ForumsRetatrutide & Triple AgonistsRetatrutide mechanism: GLP-1/GIP/glucagon triple agonism explained — anyone have experience? Page 5

Retatrutide mechanism: GLP-1/GIP/glucagon triple agonism explained — anyone have experience?

mel_PDX Sat, Mar 28, 2026 at 3:52 AM 23 replies 773 viewsPage 5 of 5
labquiet_amy
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Apr 8, 2026 at 7:57 AM#21

Adding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

26 24TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 23 others
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MarkLI_maint
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Apr 12, 2026 at 2:55 AM#22

Following on from NurseAsh_DET — and this may be the naive question:

Which effects tachyphylax and which persist, because the answer explains why tolerability improves while the appetite effect keeps working?

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Dr.Martinez
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Apr 15, 2026 at 9:51 PM#23
labquiet_amy said:
Practical: whatever you change, write down the date and the reason.

This is where I part company with the consensus forming above. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

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EndoResFellow
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Apr 19, 2026 at 4:45 PM#24
labquiet_amy said:
Practical: whatever you change, write down the date and the reason.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

Last edited: Apr 19, 2026 at 6:45 PM
29 2NurseKim_ATL, paul_denver, TinaHashiRN and 26 others
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pete_nash
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Apr 23, 2026 at 11:36 AM#25
labquiet_amy said:
Practical: whatever you change, write down the date and the reason.

This answered a question I did not know how to ask. Taking it to my next appointment.

Last edited: Apr 23, 2026 at 5:36 PM
30 3sarah.morrison, NeuroNate, JessicaH_TX and 27 others
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