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ForumsRetatrutide & Triple AgonistsRetatrutide mechanism: GLP-1/GIP/glucagon triple agonism explained — anyone have experience? Page 3

Retatrutide mechanism: GLP-1/GIP/glucagon triple agonism explained — anyone have experience?

mel_PDX Sat, Mar 28, 2026 at 3:52 AM 23 replies 773 viewsPage 3 of 5
pete_RVA
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Mar 29, 2026 at 8:58 PM#11
Dr.PulmRoch said:
The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.

Bookmarking. The distinction being drawn above is the one nobody else makes.

Last edited: Mar 30, 2026 at 1:58 AM
45 18mike_mod, SarahChen_PharmD, sarah.morrison and 42 others
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chris_chi24
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Mar 30, 2026 at 7:43 PM#12

From the other side of the consultation, briefly. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

I would rather be corrected than agreed with, if it comes to it.

Last edited: Mar 30, 2026 at 10:43 PM
46 19MounjBrad, nick_newbie, DadBodDave and 43 others
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Dr.SportsMedIN
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Mar 31, 2026 at 6:28 PM#13
james_edin said:
The pharmacokinetics explain nearly every practical question asked here.

Pushing back on james_edin here. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

47 20adam_van, Dr.SurgeonPGH, rachel_ABQ and 44 others
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lisa_labSD
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Apr 1, 2026 at 5:12 PM#14

One concrete data point for the thread. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

48 21lori_vegas, Dr.PulmRoch, maya_sedona and 45 others
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Admin
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Apr 2, 2026 at 3:56 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Thread quality here is what the rules are for. Keep it up.

49 22PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 46 others
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