BiostatsBrad said:One practical note: write down what you did and when, before you need it.
Pushing back on BiostatsBrad here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.
BiostatsBrad said:One practical note: write down what you did and when, before you need it.
Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.
BiostatsBrad said:One practical note: write down what you did and when, before you need it.
Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.
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Browse GL BiochemAdding the clinical framing, because it changes how the question reads. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.
julia.endo said:Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…
Adding a me-too, because a thread of one person's experience is not much use. The detail I would add is minor and it is already implied above.