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ForumsPublic SquareComparative pharmacokinetics: semaglutide vs tirzepatide vs retatrutide — need advice Page 8

Comparative pharmacokinetics: semaglutide vs tirzepatide vs retatrutide — need advice

emily_PDX Mon, Jul 22, 2024 at 4:07 PM 36 replies 2,470 viewsPage 8 of 8
Dr.NateNeph
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Aug 2, 2024 at 12:07 PM#36

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Last edited: Aug 2, 2024 at 2:07 PM
21 21JakeSmashed95, NauseaFreeNow, SteveThurs and 18 others
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mel_PDX
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Aug 3, 2024 at 1:42 AM#37

One thing that is still open after Dr.GutHealth’s answer:

Whether anyone has held at a sub-maximal dose long term and kept the result, or whether the maintenance data only exists at 2.4mg?

20 20Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 17 others
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bbq_ray_KC
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Aug 3, 2024 at 3:16 PM#38
Dr.NateNeph said:
Say what you would expect to see if you were wrong, before you look.

I read this differently from Dr.NateNeph, on substance rather than tone. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

Happy to go further on any of that.

19 19InsuranceTom, WendyG_ATL, SaraMom3 and 16 others
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MariaRD
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Aug 4, 2024 at 4:50 AM#39
Dr.NateNeph said:
Say what you would expect to see if you were wrong, before you look.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

Last edited: Aug 4, 2024 at 5:50 AM
18 18rick_sfbay, maria_elpaso, anders_CPH and 15 others
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EndoResFellow
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Aug 4, 2024 at 6:24 PM#40
Dr.NateNeph said:
Say what you would expect to see if you were wrong, before you look.

Bookmarking. The distinction being drawn above is the one nobody else makes. Adding it to my notes with a link back to this thread.

46 21Dr.ObesityLA, NurseKim_ATL, paul_denver and 43 others
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