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ForumsPublic SquareComparative pharmacokinetics: semaglutide vs tirzepatide vs retatrutide — need advice Page 7

Comparative pharmacokinetics: semaglutide vs tirzepatide vs retatrutide — need advice

emily_PDX Mon, Jul 22, 2024 at 4:07 PM 36 replies 2,470 viewsPage 7 of 8
Dr.EndoIndy
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Jul 30, 2024 at 4:09 PM#31
dave_SLC said:
For anyone assembling their own picture: Tmax is one to three days, terminal half-life about 165 to 170 hours, steady state at four to five weeks, and…

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

26 1mia_MS2, LeilaHI, marcus_mpls and 23 others
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RickReta_CO
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Jul 31, 2024 at 5:45 AM#32
dave_SLC said:
For anyone assembling their own picture: Tmax is one to three days, terminal half-life about 165 to 170 hours, steady state at four to five weeks, and…

This answered a question I did not know how to ask.

Last edited: Jul 31, 2024 at 10:45 AM
25 0jim_asheville, matt_MKE, Dr.ReproEndo and 22 others
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Dr.GutHealth
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Jul 31, 2024 at 7:21 PM#33

From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Worth separating that from semaglutide, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

24 24jennifer_SEA, tyler_CSCS, VanRx_Mike and 21 others
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NeuroNate
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Aug 1, 2024 at 8:57 AM#34
Dr.GutHealth said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Same experience, arrived at from the opposite direction. I had assumed I was the exception until I read this.

Last edited: Aug 1, 2024 at 2:57 PM
23 23kim_atl_prep, sarah_TO, wendy_avl and 20 others
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pat_auckland
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Aug 1, 2024 at 10:32 PM#35
Dr.GutHealth said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Coming at Dr.GutHealth’s question from a different direction. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

Last edited: Aug 2, 2024 at 2:32 AM
22 22dan_philly, MeganSA_TX, LarryQC_SD and 19 others
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