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ForumsOral GLP-1 AgonistsOrforglipron and hepatic first-pass metabolism — anyone have experience? Page 5

Orforglipron and hepatic first-pass metabolism — anyone have experience?

Dr.EM_Chicago Fri, Jan 31, 2025 at 6:59 PM 44 replies 1,967 viewsPage 5 of 9
wendy_avl
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Feb 6, 2025 at 10:26 PM#21

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

24 22SleepFixSam, PurityPaulOR, MaxMetOK and 21 others
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DanielChem_CHI
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Chicago, IL
Feb 8, 2025 at 9:44 AM#22

One thing that is still open after Dr.SurgeonPGH’s answer:

What would you measure differently if you were starting again?

25 23Dr.DermMIA, fiona_VT, denise_HTX and 22 others
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lori_vegas
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Feb 9, 2025 at 9:01 PM#23
wendy_avl said:
If you are going to change something, change one thing and give it long enough to express itself.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

26 24oliver_london, tane_welly, Dr.PathRoch and 23 others
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CanadaChris
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Toronto, CA
Feb 11, 2025 at 8:17 AM#24
wendy_avl said:
If you are going to change something, change one thing and give it long enough to express itself.

No disagreement with wendy_avl. One condition attached. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

Correct me if the detail matters more than I have assumed.

Last edited: Feb 11, 2025 at 2:17 PM
27 0Dr.PulmRoch, maya_sedona, stefan_berlin and 24 others
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GraceAZ_72
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Tucson, AZ
Feb 12, 2025 at 7:32 PM#25
wendy_avl said:
If you are going to change something, change one thing and give it long enough to express itself.

Bookmarking. The distinction being drawn above is the one nobody else makes.

Last edited: Feb 12, 2025 at 11:32 PM
28 1RetaRick_CA, JenPlateau, SallyK_inj and 25 others
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