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ForumsOral GLP-1 AgonistsOrforglipron and hepatic first-pass metabolism — anyone have experience? Page 9

Orforglipron and hepatic first-pass metabolism — anyone have experience?

Dr.EM_Chicago Fri, Jan 31, 2025 at 6:59 PM 44 replies 1,967 viewsPage 9 of 9
Dr.BariatricHTX
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Mar 8, 2025 at 2:06 AM#41
DataDave said:
One practical note: write down what you did and when, before you need it.

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

36 9CarlaRPh_TPA, steph_laguna, fiona_glasgow and 33 others
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Dr.DermMIA
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Mar 9, 2025 at 12:31 PM#42

Clinical perspective, offered as context rather than as advice. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

That is the short version; the long version is somebody else's post.

37 10Dr.RenalNash, LipidDoc_ATL, BariatricNurseD and 34 others
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Admin
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Mar 10, 2025 at 10:56 PM#43

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. No action needed from anybody.

Last edited: Mar 11, 2025 at 2:56 AM
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TinaHashiRN
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Mar 12, 2025 at 9:20 AM#44
Dr.DermMIA said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Coming at Dr.DermMIA’s question from a different direction. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

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VendorMark
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Mar 13, 2025 at 7:43 PM#45

Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

Happy to go further on any of that.

40 13claudia_zurich, nancy_portland, rick_sfbay and 37 others
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