🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsOrforglipron and hepatic first-pass metabolism — anyone have experience? Page 3

Orforglipron and hepatic first-pass metabolism — anyone have experience?

Dr.EM_Chicago Fri, Jan 31, 2025 at 6:59 PM 44 replies 1,967 viewsPage 3 of 9
Dr.ObesityMed
VIP Member
3,456
19,234
Nov 2023
Denver, CO
Online
Feb 2, 2025 at 8:44 PM#11
MASHdoc_SA said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

Last edited: Feb 3, 2025 at 2:44 AM
43 16EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 40 others
Reply Quote Save Share Report
stefan_berlin
Member
234
1,123
Oct 2024
Berlin, DE
Feb 3, 2025 at 6:32 AM#12
KevinCompounds said:
The manufacturing argument is the underrated one.

This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.

Last edited: Feb 3, 2025 at 9:32 AM
44 17JessicaH_TX, KevinCompounds, TirzTom and 41 others
Reply Quote Save Share Report
tane_welly
Member
234
1,123
Sep 2024
Wellington, NZ
Feb 3, 2025 at 4:19 PM#13
MASHdoc_SA said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Pushing back on MASHdoc_SA here. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

45 18DanielChem_CHI, marco_milano, pam_columbus and 42 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
dave_SLC
Member
345
1,567
Aug 2024
Salt Lake City, UT
Feb 4, 2025 at 2:06 AM#14

One concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

46 19FranDenver, Dr.BariatricHTX, LindaRN_retired and 43 others
Reply Quote Save Share Report
mike_mod
Moderator
7,234
19,823
Nov 2023
New York
Online
Feb 4, 2025 at 11:53 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here.

47 20PurityPaulOR, MaxMetOK, MounjBrad and 44 others
Reply Quote Save Share Report

Similar Threads

Orforglipron Phase 3 ATTAIN-1 topline — oral non-peptide GLP-116 replies
Oral semaglutide 50mg (Rybelsus HD) — OASIS program results12 replies
Danuglipron BID dosing — Pfizer oral GLP-1 update7 replies
Oral vs injectable GLP-1: bioavailability and efficacy comparison5 replies
Orforglipron food interaction profile — no fasting requirement15 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register