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ForumsPharmacology & MechanismsTachyphylaxis vs tolerance — 12 month update Page 5

Tachyphylaxis vs tolerance — 12 month update

FranDenver Mon, Dec 15, 2025 at 10:13 PM 39 replies 1,780 viewsPage 5 of 8
EndoResFellow
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Jan 8, 2026 at 7:12 AM#21
BethLabQueen said:
Keep the original post as written when you update it, and add the correction underneath.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

Correct me if the detail matters more than I have assumed.

37 10robert_kc, dan_philly, MeganSA_TX and 34 others
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tom_AK
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Jan 15, 2026 at 2:32 PM#22
BethLabQueen said:
Keep the original post as written when you update it, and add the correction underneath.

This answered a question I did not know how to ask. Printing the relevant bit and taking it with me.

Last edited: Jan 15, 2026 at 6:32 PM
38 11VanRx_Mike, steve_okc, dave_SLC and 35 others
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TinaHashiRN
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Jan 22, 2026 at 9:48 PM#23

Adding the clinical framing, because it changes how the question reads. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

39 12Dr.Martinez, mike_mod, SarahChen_PharmD and 36 others
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chris_chi24
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Jan 30, 2026 at 5:00 AM#24
TinaHashiRN said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Second this.

40 13PurityPaulOR, MaxMetOK, MounjBrad and 37 others
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LabKate
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Feb 6, 2026 at 12:08 PM#25
TinaHashiRN said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Adding the part of the answer the thread has not reached. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

Last edited: Feb 6, 2026 at 3:08 PM
41 14labquiet_amy, emily_PDX, Dr.SleepRoch and 38 others
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