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ForumsPharmacology & MechanismsTachyphylaxis vs tolerance — 12 month update Page 8

Tachyphylaxis vs tolerance — 12 month update

FranDenver Mon, Dec 15, 2025 at 10:13 PM 39 replies 1,780 viewsPage 8 of 8
cory_ATX
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Jul 2024
Austin, TX
Apr 27, 2026 at 5:02 AM#36
BethLabQueen said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

Ask again with the specifics and you will get a better answer than this one.

23 21Dr.EndoEP, GraceAZ_72, carl_compliance and 20 others
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TomTeleRx
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Feb 2025
Delaware
May 4, 2026 at 9:50 AM#37
BethLabQueen said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

Happy to go further on any of that.

24 22bri_stats, pete_manc_UK, anna.melb_AU and 21 others
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traveltech_sara
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Jan 2025
Remote, USA
May 11, 2026 at 2:35 PM#38
BethLabQueen said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Saving this. It is the first explanation that did not require me to already understand it. I will report back once I have actually tried it.

25 23wanda_boise, NurseAsh_DET, BenResearch_OR and 22 others
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KevinCompounds
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Dec 2023
Nevada
May 18, 2026 at 7:15 PM#39

Adding the clinical framing, because it changes how the question reads. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

26 24BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 23 others
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rick_sfbay
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Jan 2025
San Francisco, CA
May 25, 2026 at 11:51 PM#40
KevinCompounds said:
Start from the measurement rather than the conclusion.

Same pattern here, and in the same order.

48 21Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 45 others
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