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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsTachyphylaxis vs tolerance — 12 month update Page 3

Tachyphylaxis vs tolerance — 12 month update

FranDenver Mon, Dec 15, 2025 at 10:13 PM 39 replies 1,780 viewsPage 3 of 8
DataDave
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Dec 22, 2025 at 11:26 AM#11
Dr.CardioMD said:
I want to add the drug interaction perspective on the pharmacology.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

6 4VendorMark, COA_Karl, MikeFit_NJ and 3 others
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jason_paloalto
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Dec 24, 2025 at 3:54 AM#12
Dr.KarenChen said:
The mechanism is more central than most summaries suggest.

Bookmarking. The distinction being drawn above is the one nobody else makes.

7 5Dr.PathRoch, mona_PHX, andrew_nyc and 4 others
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DadBodDave
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Dec 25, 2025 at 8:22 PM#13
Dr.CardioMD said:
I want to add the drug interaction perspective on the pharmacology.

Pushing back on Dr.CardioMD here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

8 6pat_auckland, Dr.GastroMayo, JakeBK_lifts and 5 others
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lucas_SP_BR
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Dec 27, 2025 at 12:49 PM#14

Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

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mike_mod
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Dec 29, 2025 at 5:15 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here.

Last edited: Dec 29, 2025 at 7:15 AM
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