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ForumsDosing & ProtocolsSemaglutide PK modeling — anyone have experience? Page 7

Semaglutide PK modeling — anyone have experience?

anna.melb_AU Fri, Jan 31, 2025 at 11:07 AM 31 replies 2,196 viewsPage 7 of 7
Dr.SurgeonPGH
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Apr 11, 2025 at 5:55 AM#31
stefan_berlin said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

Last edited: Apr 11, 2025 at 8:55 AM
36 9DoseLogDan, SleepFixSam, PurityPaulOR and 33 others
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MeganSA_TX
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Apr 16, 2025 at 1:04 PM#32
stefan_berlin said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.

Last edited: Apr 16, 2025 at 3:04 PM
37 10julia.endo, JessicaM_2024, TomFromTexas and 34 others
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SarahChen_PharmD
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Apr 21, 2025 at 8:10 PM#33

Adding the clinical framing, because it changes how the question reads. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

38 11paul_denver, TinaHashiRN, robert_kc and 35 others
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tony_orlando
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Apr 27, 2025 at 3:13 AM#34
SarahChen_PharmD said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Can confirm. Same sequence, different timescale.

39 12CanadaChris, ZaraB_AL, JakeSmashed95 and 36 others
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carlos_SATX
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May 2, 2025 at 10:13 AM#35
SarahChen_PharmD said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

There is a second half to this that has not been said yet. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

That is the short version; the long version is somebody else's post.

40 13tommy_boulder, hyun_seoul, jim_asheville and 37 others
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