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ForumsDosing & ProtocolsSemaglutide PK modeling — anyone have experience? Page 6

Semaglutide PK modeling — anyone have experience?

anna.melb_AU Fri, Jan 31, 2025 at 11:07 AM 31 replies 2,196 viewsPage 6 of 7
BrianDallas92
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Mar 15, 2025 at 1:05 PM#26
NurseKim_ATL said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Same experience, arrived at from the opposite direction. I had assumed I was the exception until I read this.

10 8Dr.PathRoch, mona_PHX, andrew_nyc and 7 others
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AttorneyGrant
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Mar 20, 2025 at 9:34 PM#27
NurseKim_ATL said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Coming at NurseKim_ATL’s question from a different direction. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Last edited: Mar 20, 2025 at 10:34 PM
11 9laura_annarbor, JenMemphis, pat_auckland and 8 others
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stefan_berlin
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Mar 26, 2025 at 6:00 AM#28

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Last edited: Mar 26, 2025 at 9:00 AM
12 10KevinCompounds, TirzTom, TrialTracker_MD and 9 others
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Dr.LeslieOBGYN
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Mar 31, 2025 at 2:23 PM#29

One thing that is still open after NurseKim_ATL’s answer:

How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?

Last edited: Mar 31, 2025 at 8:23 PM
13 11NicoleRaleigh, james_edin, FranDenver and 10 others
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anna.melb_AU
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Apr 5, 2025 at 10:43 PM#30

Closing the loop on my own question.

Following this thread I went back and re-read the extension data properly. The point about trough rather than peak explains the pattern I was seeing on day six, which I had been blaming on the vial.

35 8Dr.LipidDallas, alex_tucson, kevin_tulsa and 32 others
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