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ForumsDosing & ProtocolsSteady-state concentrations across dose tiers — anyone have experience? Page 8

Steady-state concentrations across dose tiers — anyone have experience?

Dr.ReproEndo Thu, Sep 18, 2025 at 2:39 PM 47 replies 1,788 viewsPage 8 of 10
JennaRN
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Oct 4, 2025 at 6:03 PM#36
PharmacoVig_BOS said:
If you are going to change something, change one thing and give it long enough to express itself.

This is where I part company with the consensus forming above. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

33 8Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 30 others
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KevinCompounds
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Oct 5, 2025 at 2:45 PM#37
PharmacoVig_BOS said:
If you are going to change something, change one thing and give it long enough to express itself.

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

32 7Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 29 others
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MaxMetOK
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Oct 6, 2025 at 11:27 AM#38
PharmacoVig_BOS said:
If you are going to change something, change one thing and give it long enough to express itself.

Saving this. It is the first explanation that did not require me to already understand it.

31 6DoseLogDan, SleepFixSam, PurityPaulOR and 28 others
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NurseKim_ATL
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Oct 7, 2025 at 8:08 AM#39

Adding the clinical framing, because it changes how the question reads. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

30 5pete_nash, hank_denver, carlos_SATX and 27 others
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hannah_MT
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Oct 8, 2025 at 4:49 AM#40
NurseKim_ATL said:
If two explanations both fit, the useful question is which one predicts something the other does not.

Second this. Nothing to add that would improve it.

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