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ForumsNutrition & SupplementationProtein powder rankings — my results so far

Protein powder rankings — my results so far

NurseLeah_Nash Wed, Jul 2, 2025 at 2:11 PM 38 replies 1,613 viewsPage 1 of 8
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NurseLeah_Nash
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Jul 2, 2025 at 2:11 PM#1

Read the primary source rather than the write-up and the two do not agree, so here is what is actually in it.

Distribution matters less than total but it is not nothing. Roughly 25 to 40g per sitting with enough leucine to trigger synthesis, three or four times a day, is more effective than the same total in one enormous evening meal — and on a suppressed appetite the enormous evening meal is the one you will not finish anyway.

Where I think it is weakest: the subgroup findings are the part I trust least — with enough subgroups something is always significant, and these were not all pre-registered.

The question I want answered is whether the RDA is the wrong reference entirely during rapid weight loss, and what the actual target should be. Tell me what I have not thought of.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
17 12RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 14 others
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Dr.AddMedPHL
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Jul 2, 2025 at 3:10 PM#2
NurseLeah_Nash said:
Distribution matters less than total but it is not nothing.

No disagreement with NurseLeah_Nash. One condition attached. On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie. Isolate powders, Greek yoghurt and cottage cheese, egg whites, lean fish, and tinned tuna all deliver a lot of protein in a small physical volume. Front-load it: appetite is usually least suppressed in the first hours after waking and worst on the day or two after dosing, so get the majority in early in the day and early in the week.

16 11sarah_nash92, FitDadDave, RunnerRach and 13 others
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RetaRick_CA
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Jul 2, 2025 at 4:09 PM#3
NurseLeah_Nash said:
Distribution matters less than total but it is not nothing.

I will push back on the powder-first advice. It works and it also trains people out of eating food, and when the drug stops the habits are what remain. Getting protein from meals is slower and holds up better afterwards.

15 10DadBodDave, AmyNC_wife, SkepticalSean and 12 others
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Dr.PulmRoch
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Jul 2, 2025 at 5:08 PM#4

Short answer first, then the reasoning. The RDA is the wrong reference and it is worth understanding why. 0.8 g/kg is the intake at which nitrogen balance is not negative in healthy weight-stable adults — a floor for deficiency prevention, not an optimum, and derived in a population that is not in a deficit. In a substantial energy deficit, protein requirement rises because amino acids are being oxidised for energy and because muscle protein synthesis is blunted. The literature on preserving lean mass during weight loss lands around 1.4 to 2.0 g/kg of reference body weight, which is roughly two to two and a half times the RDA.

14 9DebRD_ATL, KristenIndy, MarkLI_maint and 11 others
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quinn_sf
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Jul 2, 2025 at 10:43 PM#5
Dr.AddMedPHL said:
On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

Mine went the same way, slower.

13 8Dr.EndoEP, GraceAZ_72, carl_compliance and 10 others
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