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ForumsNutrition & SupplementationMicronutrient deficiency risk on GLP-1 — B12, D, iron, zinc, folate

Micronutrient deficiency risk on GLP-1 — B12, D, iron, zinc, folate

B12Beth Mon, Jun 8, 2026 at 8:29 PM 10 replies 106 viewsPage 1 of 2
B12Beth
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Jun 8, 2026 at 8:29 PM#1

This is the version of the explanation I wish somebody had given me, written down before I forget what confused me. It is about micronutrient cover, and it is deliberately narrow — everything I am not confident about is marked as such.

What is actually established

A sustained drop to 1,100 or 1,200 calories reliably under-delivers a predictable set: B12, vitamin D, iron, folate, zinc and magnesium. Two of those are worth testing rather than guessing because the tests are cheap and the symptoms overlap with everything else — ferritin and B12. The rest a decent multivitamin covers, and there is no benefit in megadosing any of them.

The condition it depends on

The caveat that iron should be tested before supplementing, not after. Supplementing iron into normal stores is unpleasant at best and harmful in haemochromatosis.

The practical version

Cheap and worth having: ferritin, B12, vitamin D. Everything else on the deficiency list is adequately covered by a standard multivitamin at ordinary doses.

What I am not sure about

What would genuinely help is knowing which deficiencies actually show up when intake drops this far, and which are worth testing rather than supplementing blind. Not looking for reassurance. Looking for the part I have got wrong.

— B12Beth · corrections welcome and will be edited into this post with credit
1 21GraceAZ_72
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NeuroNate
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Jun 8, 2026 at 8:32 PM#2
B12Beth said:
A sustained drop to 1,100 or 1,200 calories reliably under-delivers a predictable set: B12, vitamin D, iron, folate, zinc and magnesium.

Vitamin and mineral labs to check while on micronutrients — my doctor orders these quarterly:

  • B12: Can drop due to reduced GI absorption. Mine went from 650 to 380 — now supplementing.
  • Iron/Ferritin: Reduced food intake = reduced iron. Ferritin dropped from 62 to 29. Supplementing.
  • Vitamin D: Was already low (21 ng/mL), now taking 5000 IU daily.
  • Folate: Stable, no issues.
  • Zinc: Slightly low, added a multivitamin with zinc.

Nutritional deficiencies are a real risk when you're eating significantly less. Don't skip your labs!

50 20wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 47 others
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PeptideChemSF
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Jun 8, 2026 at 8:36 PM#3
B12Beth said:
A sustained drop to 1,100 or 1,200 calories reliably under-delivers a predictable set: B12, vitamin D, iron, folate, zinc and magnesium.

Iron studies on micronutrients — important especially for women:

MarkerBaselineMonth 6After Supplementation
Ferritin632158
Iron936381
TIBC323393333
Transferrin Sat35%18%26%

My ferritin cratered at month 6 from reduced dietary intake. Iron bisglycinate 36mg with vitamin C brought it back up. Don't wait for anemia symptoms — test proactively.

Last edited: Jun 9, 2026 at 12:36 AM
49 19FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 46 others
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LindaRN_retired
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Jun 8, 2026 at 8:39 PM#4
PeptideChemSF said:
Iron studies on micronutrients — important especially for women: Marker Baseline Month 6 After Supplementation Ferritin 63 21 58 Iron 93 63 81 TIBC…

Vitamin D levels and micronutrients: an often-overlooked connection. Obese individuals store vitamin D in adipose tissue, making it less bioavailable. As you lose fat, vitamin D can actually increase WITHOUT supplementation.

My trajectory: Baseline 18 ng/mL → Month 6 (with supplement) 42 ng/mL → Month 12 48 ng/mL. Target is 40-60 ng/mL. Adequate vitamin D supports immune function, bone health, and mood — all relevant during weight loss.

48 18LondonLisa, mike_nyc, VendorMark and 45 others
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robert_kc
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Jun 8, 2026 at 8:58 PM#5
NeuroNate said:
Vitamin and mineral labs to check while on micronutrients — my doctor orders these quarterly: B12: Can drop due to reduced GI absorption.

Second this. Nothing to add that would improve it.

47 17PharmHunterJen, TomTeleRx, DoseLogDan and 44 others
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