Has anyone dealt with are all coas created equal? mine looks different from others i see?

carl_compliance said:

COA red flags for certificates of analysis — here's what to look for when reviewing a Certificate of Analysis: No HPLC data: If there's no…

My vendor review relevant to certificates of analysis: ordered 3 times from my current compounder. Consistency has been excellent.

Shipping: Next-day with cold pack
Packaging: Professional, discreet, proper labeling with lot/batch numbers
Purity: 97.4% average across orders (Janoshik verified)
Customer service: Responsive within 2 hours
Price: $148/month for semaglutide 2.4mg equivalent

greg_boulder said:

One addition: an unstated method makes a report close to uninterpretable.

Bookmarking. The distinction being drawn above is the one nobody else makes. Adding it to my notes with a link back to this thread.

carl_compliance said:

COA red flags for certificates of analysis — here's what to look for when reviewing a Certificate of Analysis: No HPLC data: If there's no…

Mass spectrometry confirmation for certificates of analysis: beyond HPLC purity, mass spec tells you the molecule's exact molecular weight. This confirms identity — not just purity.

Why this matters: HPLC can show you a "pure" compound, but if it's pure of the WRONG compound, purity is meaningless. Mass spec at m/z 4113.58 Da confirms it's actually semaglutide. My Janoshik report includes both HPLC and mass spec.

If your testing provider only offers HPLC, consider upgrading to include mass spec for at least your first batch from a new vendor.

DebRD_ATL said:

Two reports on the same product from two laboratories, four percentage points apart, and no method stated on either.

I tested my certificates of analysis batch through Janoshik — 98.1% purity. That's within acceptable range for compounded peptides. Turnaround was 14 business days.

The test costs ~$124 but gives you actual HPLC chromatography data plus mass spec confirmation. For the peace of mind alone, it's worth every penny. I test every new batch from a new vendor.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.