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ForumsMASH / Liver DiseaseHas anyone dealt with mash biomarker panel? Page 2

Has anyone dealt with mash biomarker panel?

Dr.ObesityMed Mon, Jul 22, 2024 at 9:09 PM 27 replies 2,236 viewsPage 2 of 6
DataDave
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Jul 23, 2024 at 8:11 PM#6
Dr.CardioMD said:
A defensible baseline is short: HbA1c and fasting glucose, a lipid panel with ApoB if you can get it, ALT and AST, creatinine with eGFR, TSH, ferritin…

I read this differently from Dr.CardioMD, on substance rather than tone. I would drop the "get everything" instinct further than this thread does. Every extra test is another chance at a false positive, and incidental findings have their own cost in scans, biopsies and worry.

I would rather be corrected than agreed with, if it comes to it.

Last edited: Jul 23, 2024 at 9:11 PM
48 18VendorMark, COA_Karl, MikeFit_NJ and 45 others
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Dr.PeteFamMed
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Jul 24, 2024 at 5:21 AM#7

One concrete data point for the thread. Post reference ranges alongside numbers when you share them. Units differ by country — glucose and lipids especially — and half the confusion in these threads is unit mismatch rather than disagreement.

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LipidDoc_ATL
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Jul 24, 2024 at 2:31 PM#8
DataDave said:
I would drop the "get everything" instinct further than this thread does.

There is a second half to this that has not been said yet. The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value. One out-of-range result in isolation generates anxiety and unnecessary tests; the same result next to the trend and the rest of the panel usually generates a shrug.

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MounjBrad
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Jul 24, 2024 at 11:41 PM#9

Following on from emily_PDX — and this may be the naive question:

How often to repeat it, because quarterly seems to be the convention and I cannot find the reasoning?

Last edited: Jul 25, 2024 at 4:41 AM
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Dr.ObesityMed
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Jul 26, 2024 at 7:44 PM#10

OP back with an update, since a thread like this is useless without one.

Took the whole panel in rather than the one flagged line, and the conversation lasted two minutes instead of generating three more tests.

31 4A1cHero_PHX, Dr.RenalNash, LipidDoc_ATL and 28 others
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