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ForumsMASH / Liver DiseaseLiver biopsy changes on semaglutide — looking for input Page 6

Liver biopsy changes on semaglutide — looking for input

Dr.GutHealth Sat, Oct 19, 2024 at 8:18 AM 29 replies 2,184 viewsPage 6 of 6
Dr.PeteFamMed
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Nov 10, 2024 at 9:12 AM#26
roxy_nash said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Can confirm. Same sequence, different timescale.

Last edited: Nov 10, 2024 at 10:12 AM
16 14hyun_seoul, jim_asheville, matt_MKE and 13 others
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PeptideChemSF
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Nov 12, 2024 at 6:50 PM#27
roxy_nash said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

There is a second half to this that has not been said yet. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

17 15dave_SLC, FDA_TrackerJim, ricardo_MIA and 14 others
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HPLC_Greg
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Nov 15, 2024 at 4:29 AM#28

Adding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

That is the short version; the long version is somebody else's post.

18 16RetaRick_CA, JenPlateau, SallyK_inj and 15 others
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zoe_NC
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Nov 17, 2024 at 2:09 PM#29

A narrower follow-up, since the general answer is now clear:

Whether anyone has held at a sub-maximal dose long term and kept the result, or whether the maintenance data only exists at 2.4mg?

Last edited: Nov 17, 2024 at 3:09 PM
19 17NicoleRaleigh, james_edin, FranDenver and 16 others
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Dr.GutHealth
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Nov 19, 2024 at 11:51 PM#30

Closing the loop on my own question.

Update. I did go to 2.4mg in the end, and the honest report is that it bought me less than the step before it and cost me two bad weeks. Worth knowing rather than worth repeating.

41 14MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 38 others
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