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ForumsMASH / Liver DiseaseLiver biopsy changes on semaglutide — looking for input Page 5

Liver biopsy changes on semaglutide — looking for input

Dr.GutHealth Sat, Oct 19, 2024 at 8:18 AM 29 replies 2,184 viewsPage 5 of 6
Dr.EndoEP
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Oct 29, 2024 at 9:24 AM#21

A narrower follow-up, since the general answer is now clear:

Whether normalised enzymes tell you anything about fibrosis, and what the right follow-up measurement is?

Last edited: Oct 29, 2024 at 11:24 AM
11 9NicoleRaleigh, james_edin, FranDenver and 8 others
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ben_calgary
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Oct 2024
Calgary, CA
Oct 31, 2024 at 6:55 PM#22
traveltech_sara said:
The liver data is among the strongest non-weight findings in the class.

This is where I part company with the consensus forming above. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

Last edited: Nov 1, 2024 at 12:55 AM
12 10CanadaChris, ZaraB_AL, JakeSmashed95 and 9 others
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HealthEcon_DC
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Nov 3, 2024 at 4:27 AM#23
traveltech_sara said:
The liver data is among the strongest non-weight findings in the class.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

13 11KevinCompounds, TirzTom, TrialTracker_MD and 10 others
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NicoleRaleigh
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Raleigh, NC
Nov 5, 2024 at 2:01 PM#24
traveltech_sara said:
The liver data is among the strongest non-weight findings in the class.

Saving this. It is the first explanation that did not require me to already understand it. Taking it to my next appointment.

14 12VendorMark, COA_Karl, MikeFit_NJ and 11 others
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roxy_nash
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Dec 2024
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Nov 7, 2024 at 11:36 PM#25

Adding the clinical framing, because it changes how the question reads. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Last edited: Nov 8, 2024 at 5:36 AM
15 13kim_atl_prep, sarah_TO, wendy_avl and 12 others
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