From 310 to 198 in 15 months — what worked for you?

MikeNYC_runner said:

Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several…

Plateau breaking story with a stall: I stalled at 208 lbs for 8 weeks. Tried everything — calorie cycling, increased exercise, more water. Nothing worked.

What finally broke the plateau: adding HIIT cardio 2x/week. Lost 10 lbs in the next 3 weeks. Plateaus are temporary — they always break if you stay consistent.

Dr.ObesityLA said:

Plateau breaking story with a stall: I stalled at 208 lbs for 8 weeks.

Dr.ObesityLA has the substance of this right. The condition it depends on is worth stating. Most reported plateaus are not plateaus. Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well inside the noise band. Before concluding anything, look at a rolling weekly average over at least four weeks and at a tape measure, because recomposition shows up in circumference before it shows up in weight. Then track intake honestly for a week: appetite suppression fades unevenly, and intake creeping back up is the single commonest cause.

MikeNYC_runner said:

Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several…

Can confirm. Same sequence, different timescale. I had assumed I was the exception until I read this.

Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.