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ForumsSide Effects & ManagementJoint pain improvement vs new joint pain — looking for input Page 2

Joint pain improvement vs new joint pain — looking for input

Dr.PeteFamMed Mon, Oct 27, 2025 at 2:56 PM 16 replies 1,432 viewsPage 2 of 4
anders_CPH
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Oct 27, 2025 at 5:51 PM#6
Dr.GutHealth said:
Holding genuinely reduces total burden rather than redistributing it, because the gastric-emptying component adapts.

I dislike how confidently this board tells people to push through. Incidence figures around 20 to 25% at the higher doses are class-typical, but the trials also had a discontinuation column, and "manageable with protocols" is not the same as manageable for everyone.

10 5CryptoCarl, MariaRD, AussieAnna and 7 others
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TrialTracker_MD
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Oct 27, 2025 at 6:59 PM#7

One concrete data point for the thread. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

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paige_pharma
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Oct 27, 2025 at 8:07 PM#8
anders_CPH said:
I dislike how confidently this board tells people to push through.

There is a second half to this that has not been said yet. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

8 3adam_van, Dr.SurgeonPGH, rachel_ABQ and 5 others
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PedsEndoPhilly
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Oct 27, 2025 at 9:15 PM#9

One thing that is still open after HPLC_Greg’s answer:

What distinguishes the nausea you can titrate through from the nausea that means stop?

Last edited: Oct 28, 2025 at 2:15 AM
7 2Dr.LeslieOBGYN, MikeNYC_runner and 4 others
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Dr.PeteFamMed
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Oct 28, 2025 at 2:42 AM#10

Closing the loop on my own question.

Update. It was not the dose, it was that I had stopped drinking anything because drinking made me feel full. Fixing that fixed most of it.

Last edited: Oct 28, 2025 at 3:42 AM
9 7FranDenver, Dr.BariatricHTX, LindaRN_retired and 6 others
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