Semaglutide cardiovascular benefit: SELECT trial deep dive — looking for input

MaxMetOK said:

I did go to 2.4mg in the end, and the honest report is that it bought me less than the step before it and cost me two bad weeks.

This is exactly what I could not find anywhere else. I will report back once I have actually tried it.

From the other side of the consultation, briefly.

MaxMetOK said:

...we're creating a generation dependent on cardiovascular risk...

I understand the concern, but consider this analogy: are we "creating a generation dependent on" blood pressure medication? Cholesterol medication? Thyroid medication?

Obesity is a chronic disease with biological drivers. Treating it with medication is no different from treating any other chronic condition. The "dependency" framing implies weakness or moral failure — neither of which is accurate.

If ongoing medication is what keeps someone healthy, that's successful treatment, not dependency.

Found this through search years later and it is still the best discussion of the question, so adding one thing. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

That is the short version; the long version is somebody else's post.

SleepDoc_PDX said:

MaxMetOK said: ...we're creating a generation dependent on cardiovascular risk...

There is a second half to this that has not been said yet. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Ask again with the specifics and you will get a better answer than this one.