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ForumsMASH / Liver DiseaseHas anyone dealt with de novo lipogenesis reduction on glp-1? Page 3

Has anyone dealt with de novo lipogenesis reduction on glp-1?

NurseLeah_Nash Tue, Nov 18, 2025 at 1:33 AM 34 replies 1,698 viewsPage 3 of 7
amsterdam_pete
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Nov 23, 2025 at 12:06 PM#11
NurseKim_ATL said:
Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

Last edited: Nov 23, 2025 at 6:06 PM
15 13JakeSmashed95, NauseaFreeNow, SteveThurs and 12 others
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JenMemphis
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Nov 23, 2025 at 2:53 PM#12
wanda_boise said:
ATTAIN trial (survodutide) context for liver and MASH: survodutide, a GLP-1/glucagon dual agonist, showed -18.7% body weight at 46 weeks in the Phase…

This answered a question I did not know how to ask. Sending this to two other people who asked me the same thing last week.

16 14BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 13 others
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Dr.RenalNash
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Nov 23, 2025 at 5:40 PM#13
NurseKim_ATL said:
Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

I read this differently from NurseKim_ATL, on substance rather than tone. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

17 15Dr.NutriCornell, pam_stl, wei_SG and 14 others
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Dr.PeteFamMed
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Nov 23, 2025 at 8:27 PM#14

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

18 16Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 15 others
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Admin
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Nov 23, 2025 at 11:14 PM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.

19 17PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 16 others
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