Clinical perspective, offered as context rather than as advice. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
anna.melb_AU said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
This is where I part company with the consensus forming above. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.
anna.melb_AU said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
anna.melb_AU has the substance of this right. The condition it depends on is worth stating. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.
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Browse GL Biochemanna.melb_AU said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Thank you — that is the clearest version of this I have read, and I have read a lot of them. Taking it to my next appointment.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Report rather than reply if it drifts again.