Clinical perspective, offered as context rather than as advice. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
Dr.PeteFamMed said:For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.
Genuinely useful, thank you. I had the facts and not the framework. Sending this to two other people who asked me the same thing last week.
Adding the clinical framing, because it changes how the question reads. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
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Browse GL BiochemBariatricNurseD said:The mechanism and the magnitude are separate questions.
This matches mine closely enough to be worth saying so. The dose-response is real but shallow at the top. Across STEP 1 and STEP 4 the gap between 1.7mg and 2.4mg is a couple of percentage points of body weight on average, and the average is carrying a wide spread — plenty of people at 1.7mg sit above the 2.4mg mean. If a dose is working and tolerable, "working" is the relevant variable, not "maximal".
Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.