Long-term semaglutide (3+ years) — member check-in thread

PedsEndoPhilly said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

LipidDoc_ATL said:

The mechanism that matters here is not stomach emptying, it is central.

This answered a question I did not know how to ask. Taking it to my next appointment.

PedsEndoPhilly said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Pushing back on PedsEndoPhilly here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.

The figures, for anyone assembling their own picture. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Correct me if the detail matters more than I have assumed.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.