Dr.EM_Chicago said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.
ingrid_STO said:Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were…
Saving this. It is the first explanation that did not require me to already understand it. Printing the relevant bit and taking it with me.
Dr.EM_Chicago said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.
Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
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Browse GL BiochemOne concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.