Has anyone dealt with coronary artery calcium score changes on glp-1?

anna.melb_AU said:

Lp(a) and cardiovascular risk: a nuance that matters.

Mendelian randomization evidence supporting GLP-1 pathway modulation for cardiovascular risk: genetic variants in the GLP1R gene region associated with lower BMI also show associations with reduced cardiovascular risk, confirming a causal pathway[1].

This "natural experiment" (people born with genetically higher GLP-1 signaling being leaner and healthier) provides orthogonal evidence supporting the pharmacological approach. When genetic epidemiology, clinical trials, and mechanistic studies all converge, confidence in the therapeutic approach is high.

fiona_glasgow said:

mike_nyc said: ...we're creating a generation dependent on cardiovascular risk...

This is exactly what I could not find anywhere else.

anna.melb_AU said:

Lp(a) and cardiovascular risk: a nuance that matters.

Anti-inflammatory mechanisms of GLP-1 agonists and cardiovascular risk: beyond weight loss, GLP-1R activation directly suppresses NF-κB signaling, reduces NLRP3 inflammasome activation, and decreases monocyte/macrophage adhesion to endothelium[1].

Clinical correlates: hsCRP reduction of 30-60% (consistently seen across trials), reduced carotid intima-media thickness, and decreased coronary plaque inflammation on PET imaging.

These anti-inflammatory effects likely contribute to the cardiovascular benefit seen in SELECT — and may explain benefits beyond what weight loss alone would predict.

KarenAZ_mom said:

My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.

Senior perspective on cardiovascular risk: I'm 65 years old and started this journey skeptically. My endocrinologist recommended it after years of failed interventions.

11 months later: down 53 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.

To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.