SHBG changes during weight loss on GLP-1 — July 2024

PharmacoVig_BOS said:

Hormone panel changes on the hormone panel — relevant for anyone curious about endocrine effects: Testosterone: increased 35% (weight loss reduces…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

I would rather be corrected than agreed with, if it comes to it.

InsuranceTom said:

Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

There is a second half to this that has not been said yet. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

Following on from Dr.KarenChen — and this may be the naive question:

Was that from a primary source or from a summary of one?

OP back with an update, since a thread like this is useless without one.

Resolved, and the thing that resolved it was the least interesting suggestion in the thread. Writing that down for the next person who wants the interesting answer.