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ForumsRetatrutide & Triple AgonistsWill retatrutide be the first to break 25% weight loss in Phase 3? Page 4

Will retatrutide be the first to break 25% weight loss in Phase 3?

Dr.ObesityMed Sat, May 9, 2026 at 1:48 AM 23 replies 941 viewsPage 4 of 5
PedsEndoPhilly
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May 11, 2026 at 8:38 AM#16

Adding the clinical framing, because it changes how the question reads. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

Last edited: May 11, 2026 at 1:38 PM
40 13sarah_TO, wendy_avl, jason_paloalto and 37 others
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chris_chi24
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May 11, 2026 at 4:37 PM#17
PedsEndoPhilly said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Pushing back on PedsEndoPhilly here. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

Correct me if the detail matters more than I have assumed.

41 14MounjBrad, nick_newbie, DadBodDave and 38 others
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carl_compliance
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May 12, 2026 at 12:36 AM#18
PedsEndoPhilly said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

42 15ricardo_MIA, BrianDallas92, labquiet_amy and 39 others
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pat_auckland
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May 12, 2026 at 8:36 AM#19
PedsEndoPhilly said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Saving this. It is the first explanation that did not require me to already understand it. I will report back once I have actually tried it.

Last edited: May 12, 2026 at 12:36 PM
43 16MeganSA_TX, LarryQC_SD, wanda_boise and 40 others
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mike_mod
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May 12, 2026 at 4:36 PM#20

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Report rather than reply if it drifts again.

Last edited: May 12, 2026 at 6:36 PM
15 13PurityPaulOR, MaxMetOK, MounjBrad and 12 others
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