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ForumsCardiovascular OutcomesNNT for MACE prevention — July 2024 Page 6

NNT for MACE prevention — July 2024

gary_naperville Tue, Dec 17, 2024 at 10:59 AM 36 replies 1,910 viewsPage 6 of 8
wanda_boise
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Dec 23, 2024 at 9:44 PM#26
jim_asheville said:
Metabolic syndrome resolution on cardiovascular risk: I went from meeting 4 of 5 diagnostic criteria to meeting ZERO after 12 months of treatment.

This is my experience too, for whatever a second data point is worth. Posting only so the count is not one.

4 2DanielChem_CHI, marco_milano, pam_columbus and 1 other
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jason_sac26
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Dec 24, 2024 at 12:13 PM#27
jim_asheville said:
Metabolic syndrome resolution on cardiovascular risk: I went from meeting 4 of 5 diagnostic criteria to meeting ZERO after 12 months of treatment.
jim_asheville said:
...cardiovascular risk is just another fad...

I understand the skepticism — we've all seen "miracle" weight loss solutions come and go. But consider what makes GLP-1 agonists different:

  • Phase 3 RCTs with thousands of participants (not 20-person pilot studies)
  • Published in NEJM, JAMA, Lancet (not press releases)
  • Replicated across multiple independent research groups
  • Proven cardiovascular and renal benefits beyond weight loss
  • Biological mechanism fully characterized at the receptor level

This isn't a fad — it's a new drug class supported by the highest level of clinical evidence. The comparison to past fads is understandable but inappropriate.

Last edited: Dec 24, 2024 at 2:13 PM
5 3Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 2 others
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hank_denver
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Dec 25, 2024 at 2:42 AM#28
jim_asheville said:
Metabolic syndrome resolution on cardiovascular risk: I went from meeting 4 of 5 diagnostic criteria to meeting ZERO after 12 months of treatment.

Dizziness and cardiovascular risk: I was lightheaded for the first 2 weeks. Root cause was a combination of reduced caloric intake and mild dehydration.

Fix: minimum 80-100oz water daily, don't skip meals even if you're not hungry (eat small protein-rich snacks), and stand up slowly from sitting/lying positions. Also check your blood pressure — GLP-1-induced weight loss can make BP meds too strong, requiring dose reduction.

6 4denise_HTX, raj_cambridge, ingrid_STO and 3 others
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zoe_NC
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Charlotte, NC
Dec 25, 2024 at 5:11 PM#29

One thing that is still open after jim_asheville’s answer:

What did you change at the same time, and can you separate the two now?

7 5NicoleRaleigh, james_edin, FranDenver and 4 others
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gary_naperville
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Dec 26, 2024 at 7:39 AM#30
hank_denver said:
Dizziness and cardiovascular risk: I was lightheaded for the first 2 weeks.

Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off amlodipine entirely! My cardiologist is thrilled.

If you're on BP meds and losing weight on a GLP-1, monitor your BP at home regularly. Hypotension symptoms (dizziness, lightheadedness when standing) mean your BP meds may need reduction. Don't wait for your next scheduled appointment — call your doctor.

29 2RickReta_CO, PharmHunterJen, TomTeleRx and 26 others
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