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ForumsCardiovascular OutcomesLp(a) on GLP-1 agonists — my results so far

Lp(a) on GLP-1 agonists — my results so far

mike.trainer_LA Fri, May 16, 2025 at 9:18 AM 10 replies 1,436 viewsPage 1 of 2
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mike.trainer_LA
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Apr 2024
Los Angeles, CA
May 16, 2025 at 9:18 AM#1

Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.

The question I want answered is whether an unchanged LDL-C alongside a large triglyceride fall is a good result or a bad one, because ApoB and LDL-C seem to be telling different stories.

If the honest answer is that nobody knows, that is a useful answer and I would rather have it.

9 12Dr.AddMedPHL, newstart_MO, mia_MS2 and 6 others
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Dr.RaviCardio
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May 16, 2025 at 10:13 AM#2
mike.trainer_LA said:
Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

MarkerBaselineMonth 8Clinical Meaning
LDL-P17131013Particle count (more precise than LDL-C)
Small dense LDL58%29%Atherogenic pattern
Remnant cholesterol4117Triglyceride-rich lipoproteins
oxLDL7841Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

10 13anna.melb_AU, mark_tokyo, hans_munich and 7 others
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Dr.SleepRoch
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May 16, 2025 at 11:08 AM#3
Dr.RaviCardio said:
Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel: Marker Baseline Month 8 Clinical Meaning LDL-P 1713 1013 Particle…

Tracking labs for the lipid panel — here's the panel I get every 3 months and why:

  • CMP: glucose, electrolytes, kidney function, liver enzymes
  • Lipid panel: total cholesterol, LDL, HDL, triglycerides
  • A1C: 3-month glucose average
  • hsCRP: inflammatory marker
  • CBC: blood counts, anemia screening
  • B12, folate, iron: nutritional deficiency screening
  • TSH, free T4: thyroid monitoring
  • Lipase: pancreatic safety check

Total cost with insurance: about $38 copay. Without insurance, request cash-pay pricing from Quest/Labcorp — usually $163.

Last edited: May 16, 2025 at 3:08 PM
11 14Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 8 others
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ricardo_MIA
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Sep 2024
Miami, FL
May 16, 2025 at 12:03 PM#4
mike.trainer_LA said:
Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.

Same experience, arrived at from the opposite direction. The detail I would add is minor and it is already implied above.

Last edited: May 16, 2025 at 5:03 PM
12 15KetoKyle, CanadaChris, ZaraB_AL and 9 others
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VanRx_Mike
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May 2024
Vancouver, CA
May 16, 2025 at 5:13 PM#5

From the other side of the consultation, briefly.

Comprehensive lipid panel update relevant to the lipid panel:

MarkerBaseline6 Months12 MonthsReference
Total Cholesterol265220190<200
LDL170120110<100
HDL435262>40
Triglycerides245150120<150
LDL-P15051255905<1000

The triglyceride drop is the most impressive. My cardiologist reduced my statin dose based on these results.

Last edited: May 16, 2025 at 8:13 PM
13 16mike_mod, SarahChen_PharmD, sarah.morrison and 10 others
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