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ForumsCardiovascular OutcomesLp(a) on GLP-1 agonists — my results so far Page 2

Lp(a) on GLP-1 agonists — my results so far

mike.trainer_LA Fri, May 16, 2025 at 9:18 AM 10 replies 1,436 viewsPage 2 of 2
Dr.KarenChen
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May 16, 2025 at 10:23 PM#6
Dr.RaviCardio said:
Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel: Marker Baseline Month 8 Clinical Meaning LDL-P 1713 1013 Particle…

Careful with treating an unchanged LDL-C as a failure. If ApoB and triglycerides both fell, the particle picture improved regardless of what the calculated LDL says.

14 17julia.endo, JessicaM_2024, TomFromTexas and 11 others
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BiostatsBrad
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May 17, 2025 at 3:33 AM#7
mike.trainer_LA said:
Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.

Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 3.7% to 8.2% over 12 months. I supplemented with 2g EPA+DHA daily.

This matters because omega-3s are anti-inflammatory and cardioprotective, complementing the GLP-1 benefits. Target omega-3 index is >8%. Combined with the triglyceride reduction from the medication, my lipid profile is the best it's been in decades.

15 18Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 12 others
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CarlaRPh_TPA
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May 17, 2025 at 8:42 AM#8
Dr.KarenChen said:
Careful with treating an unchanged LDL-C as a failure.

Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data:

CategoryMarkerBeforeAfter 13moChange
MetabolicA1C8.4%5.5%⬇️ 1.6%
MetabolicFasting Glucose11790⬇️ 37
LipidsLDL175104⬇️ 57
LipidsTriglycerides277107⬇️ 127
InflammationhsCRP6.51.0⬇️ 4.0

Every single metabolic marker improved. This is why I'm a believer in this therapy.

16 19BrianDallas92, labquiet_amy, emily_PDX and 13 others
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EndoResFellow
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May 17, 2025 at 1:51 PM#9

Following on from Dr.SleepRoch — and this may be the naive question:

Did your prescriber agree with that reading, and if not what was their objection?

17 20NurseKim_ATL, paul_denver, TinaHashiRN and 14 others
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mike.trainer_LA
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May 18, 2025 at 2:35 PM#10

OP back with an update, since a thread like this is useless without one.

Update — I was wrong in the opening post, specifically about the direction. Correcting it here rather than editing it away.

Last edited: May 18, 2025 at 6:35 PM
17 15marcus_mpls, DeniseRN_TPA, SandraNC_45 and 14 others
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