I was on CPAP before starting and my most recent study came back changed enough that the conversation about it is now a different conversation.
The question I want answered is what people did about re-titration, because feeling better is not the same as a study saying you are better.
I would rather have one careful answer than five confident ones.
Taking the question as asked, rather than the general version of it. SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1. Different trials, different populations, so the comparison is indicative rather than decisive — but SURPASS-2 was a genuine head-to-head and it pointed the same way.
LarryQC_SD said:SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1.
True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of people never reach the dose the headline number came from.
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View ResultsTinaHashiRN said:I was on CPAP before starting and my most recent study came back changed enough that the conversation about it is now a different conversation.
Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg. It is still the best direct evidence available, but it is not the comparison most people think they are citing.
Clinical perspective, offered as context rather than as advice.
Sleep changes on sleep apnoea: anyone else sleeping differently? I've been sleeping more deeply since starting week 4.
My theory: the weight loss has improved my sleep apnea (confirmed by recent sleep study — AHI dropped from 25 to 6). Better oxygenation at night = better sleep quality = more energy during the day. It's a virtuous cycle.