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ForumsTirzepatide (Mounjaro / Zepbound)Has anyone dealt with surmount-osa: tirzepatide and sleep apnea ahi reduction? Page 5

Has anyone dealt with surmount-osa: tirzepatide and sleep apnea ahi reduction?

TinaHashiRN Sat, Apr 26, 2025 at 12:17 PM 23 replies 1,672 viewsPage 5 of 5
VendorMark
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May 2, 2025 at 2:03 AM#21

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

44 19DebRD_ATL, KristenIndy, MarkLI_maint and 41 others
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pat_auckland
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May 3, 2025 at 4:30 AM#22

One thing that is still open after JenPlateau’s answer:

How much of the tirzepatide advantage is the GIP component and how much is simply that the dose ladder goes higher in receptor-occupancy terms?

Last edited: May 3, 2025 at 8:30 AM
43 18wanda_boise, NurseAsh_DET, BenResearch_OR and 40 others
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BiostatsBrad
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May 4, 2025 at 6:57 AM#23
VendorMark said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Pushing back on VendorMark here. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.

Happy to go further on any of that.

42 17FranDenver, Dr.BariatricHTX, LindaRN_retired and 39 others
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wanda_boise
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May 5, 2025 at 9:23 AM#24
VendorMark said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

Last edited: May 5, 2025 at 2:23 PM
41 16nick_SD_fit, ben_calgary, patPC_UT and 38 others
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anna.melb_AU
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May 6, 2025 at 11:48 AM#25
VendorMark said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

40 15Dr.LipidDallas, alex_tucson, kevin_tulsa and 37 others
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