NurseKim_ATL said:The useful move here is to separate what is established from what is widely repeated.
Same pattern here, and in the same order. Posting only so the count is not one.
NurseKim_ATL said:The useful move here is to separate what is established from what is widely repeated.
There is a second half to this that has not been said yet. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.
Adding the numbers, since they settle part of this. For anyone assembling their own picture: Tmax is one to three days, terminal half-life about 165 to 170 hours, steady state at four to five weeks, and subcutaneous bioavailability near 89%. Those four numbers explain most of the questions people ask about timing.
Worth separating that from semaglutide, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
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Shop Reference StandardsFollowing on from NurseKim_ATL — and this may be the naive question:
How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?
Reporting back.
Update. I did go to 2.4mg in the end, and the honest report is that it bought me less than the step before it and cost me two bad weeks. Worth knowing rather than worth repeating.