FLOW trial: semaglutide renal outcomes — need advice

Adding the clinical framing, because it changes how the question reads.

Kidney function labs on renal function — good news for anyone concerned about renal effects:

The FLOW trial demonstrated renal protective effects of semaglutide. My nephrologist is encouraged by the UACR improvement especially.

From the other side of the consultation, briefly. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

KevinCompounds said:

It helps to say which part of this you are uncertain about.

Adding a me-too, because a thread of one person's experience is not much use.

KevinCompounds said:

It helps to say which part of this you are uncertain about.

There is a second half to this that has not been said yet. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.

Moderator note: the sourcing question belongs in the vendor section and has been split out.