A narrower follow-up, since the general answer is now clear:
How much of the SELECT benefit is plausibly independent of the weight loss, and whether that distinction changes anything practical?
Dr.EndoEP said:The useful move here is to separate what is established from what is widely repeated.
I read this differently from Dr.EndoEP, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.
Dr.EndoEP said:The useful move here is to separate what is established from what is widely repeated.
That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.
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View ResultsDr.EndoEP said:The useful move here is to separate what is established from what is widely repeated.
Saving this. It is the first explanation that did not require me to already understand it. Adding it to my notes with a link back to this thread.
Adding the clinical framing, because it changes how the question reads. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.