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ForumsCardiovascular OutcomesGLP-1 and peripheral arterial disease — anyone have experience?

GLP-1 and peripheral arterial disease — anyone have experience?

Dr.DermMIA Fri, Sep 26, 2025 at 11:09 PM 7 replies 1,185 viewsPage 1 of 2
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Dr.DermMIA
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Miami, FL
Sep 26, 2025 at 11:09 PM#1

Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.

So the question, as narrowly as I can put it: how much of the SELECT benefit is plausibly independent of the weight loss, and whether that distinction changes anything practical.

I would rather have one careful answer than five confident ones.

45 23LipidDoc_ATL, BariatricNurseD, MASHdoc_SA and 42 others
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Dr.PainCLE
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Cleveland, OH
Sep 26, 2025 at 11:57 PM#2
Dr.DermMIA said:
Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.

Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my key markers:

Weight: consistent downtrend, -1.6 lbs/week average
Fasting glucose (finger stick): stable at 87 mg/dL
Blood pressure (home): 116/73 average
Resting heart rate: 67 bpm (down from 83)
Waist circumference: down 17 inches total

The resting heart rate improvement correlates with cardiovascular fitness gains. Everything is moving in the right direction.

Last edited: Sep 27, 2025 at 2:57 AM
46 24tane_welly, Dr.PathRoch, mona_PHX and 43 others
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JakeBK_lifts
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Jul 2024
Brooklyn, NY
Sep 27, 2025 at 12:45 AM#3
Dr.PainCLE said:
Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my…

Senior perspective on cardiovascular risk: I'm 63 years old and started this journey skeptically. My endocrinologist recommended it after years of failed interventions.

15 months later: down 41 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.

To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.

Last edited: Sep 27, 2025 at 2:45 AM
47 0LabKate, kate.chem, DataDave and 44 others
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marco_milano
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Milan, IT
Sep 27, 2025 at 1:33 AM#4
Dr.DermMIA said:
Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.

Adding a me-too, because a thread of one person's experience is not much use.

Last edited: Sep 27, 2025 at 5:33 AM
48 1tammy_FL, Dr.LipidDallas, alex_tucson and 45 others
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sarah_TO
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Sep 2024
Toronto, CA
Sep 27, 2025 at 6:06 AM#5

From the other side of the consultation, briefly.

Metabolic syndrome resolution on cardiovascular risk: I went from meeting 4 of 5 diagnostic criteria to meeting ZERO after 9 months of treatment.

The 5 criteria (and my journey):

  1. Waist circumference: 48" → 34" ✅ Resolved
  2. Triglycerides: 268 → 98 ✅ Resolved
  3. HDL: 32 → 60 ✅ Resolved
  4. Blood pressure: 148/90 → 121/75 ✅ Resolved
  5. Fasting glucose: 118 → 84 ✅ Resolved

Metabolic syndrome reversal is, in my view, the most medically significant outcome of GLP-1 therapy.

49 2DanielChem_CHI, marco_milano, pam_columbus and 46 others
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