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ForumsPublic SquareAmylin co-agonism: CagriSema REDEFINE results and implications — 6 month update Page 7

Amylin co-agonism: CagriSema REDEFINE results and implications — 6 month update

Dr.SportsMedIN Wed, Apr 16, 2025 at 10:44 AM 31 replies 1,645 viewsPage 7 of 7
josh_phd_bmore
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Baltimore, MD
Apr 24, 2025 at 11:02 PM#31
Dr.SportsMedIN said:
Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

Second this.

37 10NurseKim_ATL, paul_denver, TinaHashiRN and 34 others
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fiona_glasgow
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Glasgow, UK
Apr 25, 2025 at 1:15 PM#32
Dr.SportsMedIN said:
Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

Adding the part of the answer the thread has not reached. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

38 11TirzTom, TrialTracker_MD, JennaRN and 35 others
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DanielChem_CHI
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Apr 26, 2025 at 3:28 AM#33

One concrete data point for the thread. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

39 12patPC_UT, Dr.DermMIA, fiona_VT and 36 others
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JenMemphis
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Memphis, TN
Apr 26, 2025 at 5:42 PM#34

One thing that is still open after Dr.SportsMedIN’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

40 13wanda_boise, NurseAsh_DET, BenResearch_OR and 37 others
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Dr.GastroMayo
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Apr 27, 2025 at 7:56 AM#35
DanielChem_CHI said:
One habit that pays for itself: post the method alongside the number.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

41 14InsuranceTom, WendyG_ATL, SaraMom3 and 38 others
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