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ForumsPublic SquareAmylin co-agonism: CagriSema REDEFINE results and implications — 6 month update Page 6

Amylin co-agonism: CagriSema REDEFINE results and implications — 6 month update

Dr.SportsMedIN Wed, Apr 16, 2025 at 10:44 AM 31 replies 1,645 viewsPage 6 of 7
laura_annarbor
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Dec 2024
Ann Arbor, MI
Apr 22, 2025 at 12:31 AM#26

One thing that is still open after Dr.KarenChen’s answer:

How would you tell the difference between that and the alternative explanation?

11 9labquiet_amy, emily_PDX, Dr.SleepRoch and 8 others
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maria_elpaso
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Sep 2024
El Paso, TX
Apr 22, 2025 at 2:35 PM#27
TrialTracker_MD said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

12 10RunnerRach, TrialNerd_Beth, HPLC_Greg and 9 others
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mark_tokyo
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Apr 23, 2025 at 4:39 AM#28
TrialTracker_MD said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

13 11LibrarianMeg, bri_stats, pete_manc_UK and 10 others
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LarryQC_SD
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Jan 2024
San Diego, CA
Apr 23, 2025 at 6:44 PM#29
TrialTracker_MD said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

This answered a question I did not know how to ask. Printing the relevant bit and taking it with me.

14 12robert_kc, dan_philly, MeganSA_TX and 11 others
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Dr.SportsMedIN
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Indianapolis, IN
Apr 24, 2025 at 8:49 AM#30

OP back with an update, since a thread like this is useless without one.

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect. Two curves, and I had been watching the wrong one.

36 9rachel_ABQ, traveltech_sara, AttorneyGrant and 33 others
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