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ForumsPublic SquareMuscle protein synthesis rates on GLP-1 — 6 month update Page 5

Muscle protein synthesis rates on GLP-1 — 6 month update

PedsEndoPhilly Wed, Sep 10, 2025 at 9:45 PM 31 replies 1,627 viewsPage 5 of 7
PharmacoVig_BOS
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Sep 23, 2025 at 6:34 AM#21

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

34 9amsterdam_pete, LondonLisa, mike_nyc and 31 others
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tony_orlando
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Sep 26, 2025 at 1:56 AM#22

Following on from hans_munich — and this may be the naive question:

Whether resistance training and protein change the ratio or only the absolute amount?

Last edited: Sep 26, 2025 at 2:56 AM
33 8JakeSmashed95, NauseaFreeNow, SteveThurs and 30 others
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Dr.SurgeonPGH
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Sep 28, 2025 at 9:20 PM#23
PharmacoVig_BOS said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

This is where I part company with the consensus forming above. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

Worth separating that from lean-mass preservation, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: Sep 29, 2025 at 12:20 AM
32 7PharmHunterJen, TomTeleRx, DoseLogDan and 29 others
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amy_econ_NJ
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Oct 1, 2025 at 4:45 PM#24
PharmacoVig_BOS said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

31 6gary_naperville, sean_dublin, hannah_MT and 28 others
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SleepDoc_PDX
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Oct 4, 2025 at 12:12 PM#25
PharmacoVig_BOS said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

That reframing is the part I needed.

Last edited: Oct 4, 2025 at 3:12 PM
30 5mel_PDX, Dr.AddMedPHL, newstart_MO and 27 others
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